NeuroMMSig - clinical validation of candidate mechanisms

Currently, we are working on validating the mechanism inventory with clinical cohorts in the Alzheimer’s and Parkinson’s field such as AddNeuroMed, Alzheimer's Disease Neuroimaging Initiative (ADNI), or Parkinson’s Progression Markers Initiative (PPMI). For that we are using some of the methodologies described in the Data Mining area.

Figure: Schematic representation of NeuroMMSig and the different multi-scale mechanisms contained on it.

Domingo-Fernández, D., Kodamullil, A. T., Iyappan, A., Naz, M., Emon, M. A., Raschka, T., ... & Hofmann-Apitius, M. (2017). Multimodal Mechanistic Signatures for Neurodegenerative Diseases (NeuroMMSig): a web server for mechanism enrichment. Bioinformatics, 33(22), 3679-3681.