Links between ADNI-derived BN in PD

To investigate how the dependencies identified from the BN might overlap with Parkinson’s disease. We conducted the same exercise mapping the BN nodes this time with NeuroMMSig PD. The rationale behind this was to examine whether these links might also overlap with NeuroMMSig PD mechanisms. Furthermore, we intend to compare the generated networks to see whether common players might be revealed suggesting potential comorbidity factors.

As a result, 24 mapping KEGG/Reactome pathways were mapped to NeuroMMSig PD mechanisms (39 were mapped to NeuroMMSig AD) and six of the twelve links could be reconstructed using the PD OpenBEL model with the same methodology. The figure above shows two of the networks and summarizes the results. It can be easily seen how the generated networks present relative smaller density and size when compared to their AD analogous. This is due to the fact that the PD modeling program started later in the project so there is smaller amount of literature assembled in the models. This is also represented in the number of NeuroMMSig subgraphs for each disease: 65 for PD and 125 for AD.

Figure: Generation of mechanistic networks from the observed links in the BN using the Parkinson’s disease OpenBEL model.